copyright dodecyl O-glucoside-based vesicles as nanocarriers for catechin laurate

copyright dodecyl O-glucoside-based vesicles as nanocarriers for catechin laurate

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In this work, copyright dodecyl O-glucoside-based vesicles were successfully developed employing (+)-catechin (C) and (−)-epigallocatechin (EGC) laurate as model compounds.Results revealed that vesicles displayed high loading capacity for both C and EGC laurate and the incorporation of C or EGC laurate were confirmed by dynamic light scattering, transmission electron microscope, Fourier-transform infrared spectra, and differential scanning calorimetry analyses.C and EGC laurate stiffened the Cockatil Tools vesicle bilayer at low concentrations but created a remarkable increase in the membrane fluidity afterward.

Vesicles readily underwent aggregation under thermal treatment and osmotic stress.The thermal stability MENS BASIC TEES of C and EGC laurate were significantly improved by vesicle encapsulation.Compared with C and EGC, encapsulated C and EGC laurate exhibited lower 2,2′-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid (ABTS) radical-scavenging activity due to the shielding effect of vesicles but higher lipid-oxidation inhibitory ability because they preferentially concentrated in the liposome membrane.